Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. SHMT1, serine hydroxymethyltransferase 1 (soluble)
Sequence ID:NM_004169
RefSeqGene ID:NG_017111
Entrez Gene ID:6470
Ensembl ID:ENSG00000176974

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, salivary gland, skin, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:17p11.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 18259292 - 18266856

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3687873Full LengthBC007979serine hydroxymethyltransferase 1 (soluble)
4108106Full LengthBC022874serine hydroxymethyltransferase 1 (soluble)
4523709Full LengthBC038598serine hydroxymethyltransferase 1 (soluble)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_683718  NP_004160  

Protein Infomation

NM_004169 NP_004160 P34896 EC SHMT
NM_148918 NP_683718     SHMT

Related Sequences

L23928 AAA36018 P34896 EC
L23928 AAA36019 P34896 EC
L23928 AAA36020 P34896 EC
L11931 AAA63257 P34896 EC
AF017065 AAC39726    
BC007979 AAH07979 P34896 EC
BC022874 AAH22874 P34896 EC
BC038598 AAH38598 P34896 EC
DQ893242 ABM84168    
EU176779 ABW03580    
AK223552 BAD97272 Q53ET7  
AK298415 BAG60641 B4DPM9  
AK302834 BAG64027 B4DZB5  
Y14485 CAB54838 P34896 EC
Y14486 CAB54839 P34896 EC
Y14488 CAB54841 Q9UMD0  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens SHMT1 NP_004160 M.musculus Shmt1 20425 Gene Info NP_033197 92
R.norvegicus Shmt1 287379   NP_001041307 91
A.gambiae AgaP_AGAP001065 1278659   XP_318298 66
C.elegans mel-32 175915   NP_741197 62
D.melanogaster CG3011 31524   NP_572278 60
A.thaliana SHM1 829949   NP_195506 60
N.crassa NCU05805 3876196   XP_960065 58
S.pombe shm2 2542242   NP_593668 56
S.cerevisiae SHM1 852565   NP_009822 55

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)