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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. PTPN11, Protein tyrosine phosphatase, non-receptor type 11
Sequence ID:NM_002834
RefSeqGene ID:NG_007459
Entrez Gene ID:5781
Ensembl ID:ENSG00000179295

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 112856757 - 112943739

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3872007Full LengthBC008692protein tyrosine phosphatase, non-receptor type 11
4303171IncompleteBC007869protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)

Protein Infomation

NM_002834 NP_002825    
NM_080601 NP_542168    

Related Sequences

L07527 AAA17022 Q06124 EC
L03535 AAA36611 Q06124 EC
S78088 AAB21148 Q16344  
BC008692 AAH08692 Q06124 EC
BC025181 AAH25181 Q96I26  
BC030949 AAH30949 Q96I26  
BT007106 AAP35770 Q06124 EC
EU779706 ACE60554 B3GUD3  
EU779707 ACE60555 B3GUD4  
EU779708 ACE60556 B3GUD5  
D13540 BAA02740 Q06124 EC
AK289854 BAF82543 Q06124 EC
AK312147 BAG35082 Q96I26  
X70766 CAA50045 Q06124 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens PTPN11 NP_002825 R.norvegicus Ptpn11 25622   NP_037220 99
M.musculus Ptpn11 19247 Gene Info NP_035332 99
D.melanogaster csw 45278   NP_477130 66
A.gambiae AgaP_AGAP002438 1273523   XP_563746 65
C.elegans ptp-2 174003   NP_495184 44

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta