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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. SH2B3, SH2B adaptor protein 3
Sequence ID:NM_005475
RefSeqGene ID:NG_021216
Entrez Gene ID:10019
Ensembl ID:ENSG00000111252

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
DIABETES MELLITUS, INSULIN-DEPENDENTFOXP3
HLA-DQB1
HLA-DQB1
HNF1A
ITPR3
OAS1
PTPN22
ERYTHROCYTOSIS, SOMATICEPOR
JAK2
MYELOFIBROSIS WITH MYELOID METAPLASIA, SOMATICJAK2
MPL
THROMBOCYTHEMIA 1JAK2
MPL
THPO
THPO

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 111856356 - 111889426

NM_005475 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
1330111843751111844080
3311089111855922111856680
10901191111884556111884657
11921283111884745111884836
12841378111884928111885022
13791593111885133111885347
15941765111885459111885630
17665405111885786111889425

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9020440Full LengthBC136451SH2B adaptor protein 3

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005466  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005475 NP_005466 Q9UQQ2 SH2
PH

Related Sequences

 
mRNAGenPeptSwissProt
AF055581 AAC71695 Q9UQQ2
BC015786 AAH15786 Q96BA5
BC136451 AAI36452 Q9UQQ2
AB208911 BAD92148 Q59H48
AK302173 BAH13642 B7Z7K6
AJ012793 CAB42642 Q9UQQ2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens SH2B3 NP_005466 M.musculus Sh2b3 16923 Gene Info NP_032533 78

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)