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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. -, Transcribed locus, strongly similar to NP_001244316.1 serine/threonine-protein kinase Chk2 isoform d [Homo sapiens]
Sequence ID:BP420084
RefSeqGene ID:NG_008150
Entrez Gene ID:11200
Ensembl ID:ENSG00000183765

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssemblies

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3
OSTEOSARCOMARB1
TNFRSF11A
TNFRSF11A
TP53
TP53
PROSTATE CANCERAR
BRCA2
CD82
CDH1
ELAC2
HIP1
HIP1
HNF1B
KLF6
KLF6
MAD1L1
MSR1
MXI1
MXI1
PTEN
TUSC3
TUSC3
ZFHX3

Cytogenetic Location (from UniGene)

Cytogenetic Location:Unknown

Chromosomal Position (from UCSC)

Chromosomal Position:Unknown


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3532866Full LengthBC004207CHK2 checkpoint homolog (S. pombe)

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001005735 NP_001005735     Pkinase
FHA
Pkinase_Tyr
NM_001257387 NP_001244316      
NM_007194 NP_009125 O96017 EC 2.7.11.1 Pkinase
FHA
NM_145862 NP_665861     Pkinase
FHA
Pkinase_Tyr

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF086904 AAC83693 O96017 EC 2.7.11.1
AF096279 AAD11784 O96017 EC 2.7.11.1
AF174135 AAD48504 O96017 EC 2.7.11.1
AF217975 AAG17218 Q9HBS5  
BC004207 AAH04207 O96017 EC 2.7.11.1
AY551295 AAS58456 O96017 EC 2.7.11.1
AY551296 AAS58457 O96017 EC 2.7.11.1
AY551297 AAS58458 O96017 EC 2.7.11.1
AY551298 AAS58459 O96017 EC 2.7.11.1
AY551299 AAS58460 O96017 EC 2.7.11.1
AY551300 AAS58461 O96017 EC 2.7.11.1
AY551301 AAS58462 O96017 EC 2.7.11.1
AY551302 AAS58463 O96017 EC 2.7.11.1
AY551303 AAS58464 O96017 EC 2.7.11.1
AY551304 AAS58465 O96017 EC 2.7.11.1
AY551305 AAS58466 O96017 EC 2.7.11.1
DQ893133 ABM84059    
DQ896413 ABM87412    
AB040105 BAB17231 O96017 EC 2.7.11.1
AK289360 BAF82049 A8JZZ5  
AK290754 BAF83443 O96017 EC 2.7.11.1
AJ131197 CAA10319 O96017 EC 2.7.11.1
CR456418 CAG30304 O96017 EC 2.7.11.1
AJ783839 CAH04270 Q683Z8  
CU012979 CAK54410    
CU013267 CAK54709    

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CHEK2 NP_009125 R.norvegicus Chek2 114212   NP_446129 86
M.musculus Chek2 50883 Gene Info NP_057890 85
N.crassa NCU02814 3880610   XP_964470 43
D.melanogaster lok 35288   NP_477218 42
C.elegans chk-2 180304   NP_001024271 36
A.gambiae AgaP_AGAP009784 1279197   XP_318879 35
C.elegans T08D2.7 191613   NP_508060 35

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta