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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. CBL, Cbl proto-oncogene, E3 ubiquitin protein ligase
Sequence ID:NM_005188
RefSeqGene ID:NG_016808
Entrez Gene ID:867
Ensembl ID:ENSG00000110395

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, pancreas, pancreatic islet, peripheral nervous system, pineal gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILEMEYLOMONOCYTIC LEUKEMIA 

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q23.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 119174723 - 119177651

 Exon Info From UCSC:
NM_005188

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9020452Full LengthBC136463Cas-Br-M (murine) ecotropic retroviral transforming sequence
40146755Full LengthBC132733Cas-Br-M (murine) ecotropic retroviral transforming sequence

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005179  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005188 NP_005179 P22681 zf-C3HC4
UBA
Cbl_N
Cbl_N2
Cbl_N3

Related Sequences

 
mRNAGenPeptSwissProt
BC132733 AAI32734 P22681
BC136463 AAI36464 P22681
X57110 CAA40393 P22681

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CBL NP_005179 M.musculus Cbl 12402 Gene Info NP_031645 94
R.norvegicus Cbl 500985   XP_576396 93
C.elegans sli-1 180419   NP_001024798 51
D.melanogaster Cbl 38961   NP_648224 51
A.gambiae AgaP_AGAP005449 3289969   XP_556087 49

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta