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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TYR, tyrosinase
Sequence ID:NM_000372
RefSeqGene ID:NG_008748
Entrez Gene ID:7299
Ensembl ID:ENSG00000077498

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ALBINISM, OCULOCUTANEOUS, TYPE IA 
ALBINISM, OCULOCUTANEOUS, TYPE IB 
MELANOMA, CUTANEOUS MALIGNANT 
WAARDENBURGSYNDROME/ALBINISM, DIGENICMITF
MITF

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q14-q21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 88911060 - 88933770

NM_000372 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
19018891103988911939
90211188892436988924585
111912668896099088961137
126714488901794089018121
144920648902831089028925

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3923096Full LengthBC027179tyrosinase (oculocutaneous albinism IA)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000363  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000372 NP_000363 P14679 EC 1.14.18.1 Tyrosinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J03581 AAA61241 P14679 EC 1.14.18.1
M74314 AAA61244 P14679 EC 1.14.18.1
M27160 AAB37227 P14679 EC 1.14.18.1
U01873 AAB60319 P14679 EC 1.14.18.1
S66645 AAD13984 Q9UMA2  
BC027179 AAH27179 P14679 EC 1.14.18.1
Y00819 CAA68756 P14679 EC 1.14.18.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TYR NP_000363 R.norvegicus Tyr 308800   NP_001101005 87
M.musculus Tyr 22173 Gene Info NP_035791 86

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)