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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MGMT, O-6-methylguanine-DNA methyltransferase
Sequence ID:NM_002412
Entrez Gene ID:4255
Ensembl ID:ENSG00000170430

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:10q26Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 131265477 - 131565884

NM_002412 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
1107131265453131265559
108244131334504131334640
245393131506158131506306
394533131557465131557604
5341265131565051131565782

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3454207Full LengthBC000824O-6-methylguanine-DNA methyltransferase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002403  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002412 NP_002403 P16455 EC 2.1.1.63 DNA_binding_1
Methyltransf_1N

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M31767 AAA52317 P16455 EC 2.1.1.63
M60761 AAA59594 P16455 EC 2.1.1.63
M29971 AAA59596 P16455 EC 2.1.1.63
BC000824 AAH00824 P16455 EC 2.1.1.63
BT006714 AAP35360 P16455 EC 2.1.1.63
DQ890723 ABM81649    
DQ893901 ABM84827    
AK293593 BAG57059 B4DEE8  
X54228 CAA38137 P16455 EC 2.1.1.63

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MGMT NP_002403 M.musculus Mgmt 17314 Gene Info NP_032624 71
R.norvegicus Mgmt 25332   NP_036993 71

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)