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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. GOT1, glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
Sequence ID:NM_002079
RefSeqGene ID:NG_032044
Entrez Gene ID:2805
Ensembl ID:ENSG00000120053

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ASPARTATE AMINOTRANSFERASE, SERUM LEVEL OF, QTL1 

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q24.1-q25.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 101157043 - 101190350

NM_002079 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
15830101156627101157442
831973101162336101162478
9741139101163225101163390
11401290101163480101163630
12911395101165512101165616
13961508101165893101166005
15091632101166482101166605
16331814101180380101180561
18152140101190204101190529

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2820849Full LengthBC000498glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002070  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002079 NP_002070 P17174 EC 2.6.1.1 Aminotran_1_2

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M37400 AAA35563 P17174 EC 2.6.1.1
AF052153 AAC28622 P17174 EC 2.6.1.1
BC000498 AAH00498 P17174 EC 2.6.1.1
AY513279 AAT08032 Q2TU84  
AK312684 BAG35564 P17174 EC 2.6.1.1
AK293483 BAH11518 B7Z1I2  
AK301916 BAH13585 B7Z7E9  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens GOT1 NP_002070 M.musculus Got1 14718 Gene Info NP_034454 91
R.norvegicus Got1 24401   NP_036703 90
A.gambiae AgaP_AGAP004142 1273967   XP_313023 61
D.melanogaster Got1 36782   NP_725534 57
C.elegans aminotransferase 181726   NP_510709 54
N.crassa NCU07941 3878589   XP_962457 53
A.thaliana ASP3 831024   NP_196713 51
S.cerevisiae AAT2 850714   NP_013127 48
S.pombe SPAC10F6.13c 2543020   NP_593264 47

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta