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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. IDE, insulin-degrading enzyme
Sequence ID:NM_001165946
RefSeqGene ID:NG_013012
Entrez Gene ID:3416
Ensembl ID:ENSG00000119912

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q23-q25Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 94213850 - 94266249

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40008464Full LengthBC096336insulin-degrading enzyme
40008465Full LengthBC096337insulin-degrading enzyme
40008468Full LengthBC096339insulin-degrading enzyme

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004960  

Protein Infomation

NM_001165946 NP_001159418      
NM_004969 NP_004960 P14735 EC Peptidase_M16

Related Sequences

M21188 AAA52712 P14735 EC
BC096336 AAH96336 P14735 EC
BC096337 AAH96337 P14735 EC
BC096339 AAH96339 P14735 EC
AB209204 BAD92441 Q59GA5  
AK312810 BAG35668 P14735 EC
AK093287 BAG52680 B3KSB8  
AK302578 BAH13752 B7Z7W6  
AK316407 BAH14778 P14735 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens IDE NP_004960 R.norvegicus Ide 25700   NP_037291 95
M.musculus Ide 15925 Gene Info NP_112419 95
A.gambiae AgaP_AGAP010351 1272688   XP_311589 47
D.melanogaster Ide 40248   NP_524182 47
C.elegans peptidase 178966   NP_741542 44
N.crassa NCU00481 3872313   XP_956166 43
C.elegans peptidase 182128   NP_504531 42
C.elegans Y70C5C.1 190566   NP_507226 41
C.elegans peptidase 182127   NP_504532 41
A.thaliana AT3G57470 824914   NP_001118852 39
S.pombe mug138 2542436   NP_593966 39
A.thaliana AT2G41790 818778   NP_181710 39
S.cerevisiae STE23 851105   NP_013493 39
C.elegans insulinase 182987   NP_495575 38

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)