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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. ACTA2, actin, alpha 2, smooth muscle, aorta
Sequence ID:NM_001141945
NM_001613
RefSeqGene ID:NG_011541
Entrez Gene ID:59
Ensembl ID:ENSG00000107796

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
AORTIC ANEURYSM, FAMILIAL THORACIC 6 
MOYAMOYA DISEASE 5 
MULTISYSTEMICSMOOTH MUSCLE DYSFUNCTION SYNDROME 

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q23.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 90706049 - 90707733

 Exon Info From UCSC:
NM_001141945
NM_001613

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3906861Full LengthBC017554actin, alpha 2, smooth muscle, aorta
30351093Full LengthBC093052actin, alpha 2, smooth muscle, aorta

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001604  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001141945 NP_001135417    
NM_001613 NP_001604 P62736 Actin

Related Sequences

 
mRNAGenPeptSwissProt
J05192 AAA51577 P62736
BC017554 AAH17554 P62736
BC093052 AAH93052 P62736
AY692464 AAW29811 P62736
DQ892391 ABM83317  
DQ895606 ABM86532  
AK313294 BAG36101 P62736
AK300664 BAG62350 B4DUI8
X13839 CAA32064 P62736
CR536518 CAG38756 P62736

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens ACTA2 NP_001135417 M.musculus Acta2 11475 Gene Info NP_031418 100
A.gambiae AgaP_AGAP011516 1275974   XP_315269 93
D.melanogaster Act88F 41885   NP_524367 93

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)