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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MTR, 5-methyltetrahydrofolate-homocysteine methyltransferase
Sequence ID:NM_000254
RefSeqGene ID:NG_008959
Entrez Gene ID:4548
Ensembl ID:ENSG00000116984

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, skin, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEUKEMIA, MEGAKARYOBLASTIC, WITH OR WITHOUT DOWN SYNDROME, SOMATICGATA1
METHYLCOBALAMIN DEFICIENCY, CBLG TYPE 
NEURAL TUBEDEFECTS, FOLATE-SENSITIVEMTHFD1
MTHFR
MTHFR
MTRR

Cytogenetic Location (from UniGene)

Cytogenetic Location:1q43Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 237064854 - 237067280

 Exon Info From UCSC:
NM_000254

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9020429Full LengthBC1364405-methyltetrahydrofolate-homocysteine methyltransferase
9052615Full LengthBC1440955-methyltetrahydrofolate-homocysteine methyltransferase
9052617Full LengthBC1440975-methyltetrahydrofolate-homocysteine methyltransferase
40146647Full LengthBC1306165-methyltetrahydrofolate-homocysteine methyltransferase
3909623IncompleteBC0158945-methyltetrahydrofolate-homocysteine methyltransferase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000245  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000254 NP_000245 Q99707 EC 2.1.1.13 Pterin_bind
B12-binding
S-methyl_trans
B12-binding_2
Met_synt_B12

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U73338 AAB39704 Q99707 EC 2.1.1.13
U75743 AAB58906 Q99707 EC 2.1.1.13
U71285 AAC51188 Q99707 EC 2.1.1.13
BC130616 AAI30617 Q99707 EC 2.1.1.13
BC136440 AAI36441 Q99707 EC 2.1.1.13
BC144095 AAI44096 B7ZLW7  
BC144097 AAI44098 B7ZLW8  
AK294270 BAG57561 B4DFV0  
AK299904 BAG61745 B4DST3  
BX641132 CAE46059 Q6MZH4  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MTR NP_000245 M.musculus Mtr 238505 Gene Info NP_001074597 92
R.norvegicus Mtr 81522   NP_110491 92
C.elegans R03D7.1 174681   NP_496353 64

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)