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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. CASK, calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Sequence ID:NM_001126054
NM_001126055
NM_003688
RefSeqGene ID:NG_016754
Entrez Gene ID:8573
Ensembl ID:ENSG00000147044

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pineal gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, stem cell, stomach, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
FG SYNDROME 4 
MENTAL RETARDATION AND MICROCEPHALY WITH PONTINE AND CEREBELLARHYPOPLASIA 

Cytogenetic Location (from UniGene)

Cytogenetic Location:Xp11.4Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:X: 41378779 - 41449204

 Exon Info From UCSC:
NM_001126054
NM_001126055
NM_003688

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9051962Full LengthBC143454calcium/calmodulin-dependent serine protein kinase (MAGUK family)
9051964Full LengthBC143456calcium/calmodulin-dependent serine protein kinase (MAGUK family)
40125862Full LengthBC117311calcium/calmodulin-dependent serine protein kinase (MAGUK family)
4334367IncompleteBC035990calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003679  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001126054 NP_001119526    
NM_001126055 NP_001119527    
NM_003688 NP_003679   Pkinase
PDZ
Guanylate_kin
L27
SH3_2

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF032119 AAB88125 O14936 EC 2.7.11.1
AF035582 AAB88198 O14936 EC 2.7.11.1
AF262404 AAF72666 O14936 EC 2.7.11.1
AF262405 AAF72667 O14936 EC 2.7.11.1
BC117311 AAI17312 O14936 EC 2.7.11.1
BC143454 AAI43455 O14936 EC 2.7.11.1
BC143456 AAI43457 B7ZKY2  
AY705392 AAU10527 O14936 EC 2.7.11.1
HQ258518 ADR83272    
AB039327 BAB12252 O14936 EC 2.7.11.1
AB208859 BAD92096 O14936 EC 2.7.11.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CASK NP_003679 M.musculus Cask 12361 Gene Info NP_033936 100
R.norvegicus Cask 29647   NP_071520 100
A.gambiae AgaP_AGAP001683 4577273   XP_001238476 65
D.melanogaster Caki 42567   NP_001163681 64
C.elegans lin-2 181400   NP_001024587 53

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta