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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TGFBR1, transforming growth factor, beta receptor 1
Sequence ID:NM_001130916
NM_004612
RefSeqGene ID:NG_007461
Entrez Gene ID:7046
Ensembl ID:ENSG00000106799

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, skin, spleen, stem cell, stomach, synovium, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LOEYS-DIETZ SYNDROME, TYPE 1A 
LOEYS-DIETZ SYNDROME,TYPE 2A 
MULTIPLE SELF-HEALING SQUAMOUS EPITHELIOMA, SUSCEPTIBLITY TO 

Cytogenetic Location (from UniGene)

Cytogenetic Location:9q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:9: 101913642 - 101915931

 Exon Info From UCSC:
NM_001130916
NM_004612

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
30344890Full LengthBC071181transforming growth factor, beta receptor 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004603  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001130916 NP_001124388      
NM_004612 NP_004603 Q5T7S2
P36897
EC 2.7.11.30 Pkinase
Activin_recp
TGF_beta_GS

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
L11695 AAA16073 Q5T7S2
P36897
EC 2.7.11.30
BC071181 AAH71181 P36897 EC 2.7.11.30
AK302059 BAG63449 B4DXN7  
AK302234 BAG63588 B4DY26  
AJ619019 CAF02096 P36897 EC 2.7.11.30
AJ619020 CAF02097 P36897 EC 2.7.11.30

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TGFBR1 NP_004603 M.musculus Tgfbr1 21812 Gene Info NP_033396 97
R.norvegicus Tgfbr1 29591   NP_036907 97
A.gambiae AgaP_AGAP012476 1269085   XP_307671 71
A.gambiae AgaP_AGAP008247 1277733   XP_317220 71
D.melanogaster babo 35900   NP_476999 60

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta