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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. NOTCH2, notch 2
Sequence ID:NM_001200001
RefSeqGene ID:NG_008163
Entrez Gene ID:4853
Ensembl ID:ENSG00000134250

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, placenta, pooled tissue, prostate, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p13-p11Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 120455704 - 120612020

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4822955Full LengthBC071562Notch homolog 2 (Drosophila)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_077719  

Protein Infomation

NM_001200001 NP_001186930    
NM_024408 NP_077719 Q04721 EGF

Related Sequences

AF308601 AAA36377 Q04721
U77493 AAB19224 Q04721
AF315356 AAG37073 Q04721
BC071562 AAH71562 Q6IQ50
GQ231534 ADB12482 D2WEZ3
AK027869 BAB55419 Q96JU8
AL133036 CAB61366 Q9UFD5

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens NOTCH2 NP_077719 M.musculus Notch2 18129 Gene Info NP_035058 93
R.norvegicus Notch2 29492   NP_077334 92

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta