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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2
Sequence ID:NM_000400
NM_001130867
RefSeqGene ID:NG_007067
Entrez Gene ID:2068
Ensembl ID:ENSG00000104884

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
CEREBROOCULOFACIOSKELETAL SYNDROME 2 
TRICHOTHIODYSTROPHYERCC3
GTF2H5
XERODERMA PIGMENTOSUM, GROUP D 

Cytogenetic Location (from UniGene)

Cytogenetic Location:19q13.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 45854852 - 45862196

 Exon Info From UCSC:
NM_000400
NM_001130867

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6044425Full LengthBC108255excision repair cross-complementing rodent repair deficiency, complementation group 2
40034047Full LengthBC110522excision repair cross-complementing rodent repair deficiency, complementation group 2
40034048Full LengthBC110523excision repair cross-complementing rodent repair deficiency, complementation group 2
3531867IncompleteBC008346excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000391  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000400 NP_000391 P18074 EC 3.6.4.12 DEAD_2
DUF1227
NM_001130867 NP_001124339      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC108255 AAI08256 P18074 EC 3.6.4.12
BC110522 AAI10523 Q2TB79  
BC110523 AAI10524 P18074 EC 3.6.4.12
BT006883 AAP35529 P18074 EC 3.6.4.12
AK130849 BAC85446 Q6ZNQ5  
AK303358 BAG64418 B4E0F6  
X52221 CAA36463 P18074 EC 3.6.4.12
X52222 CAA36464 P18074 EC 3.6.4.12

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens ERCC2 NP_000391 M.musculus Ercc2 13871 Gene Info NP_031975 98
R.norvegicus LOC100361160 100361160   XP_002728747 98
A.gambiae AgaP_AGAP002988 1272969   XP_311900 69
D.melanogaster Xpd 37414   NP_726036 69
C.elegans Y50D7A.2 175190   NP_497182 62
S.pombe rad15 2542203   NP_593025 56
A.thaliana UVH6 839557   NP_171818 55
N.crassa NCU01625 3872684   XP_956536 55
S.cerevisiae RAD3 856918   NP_011098 53
P.falciparum PFI1650w 813610   XP_001352206 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)