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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MTRR, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Sequence ID:NM_002454
NM_024010
RefSeqGene ID:NG_008856
Entrez Gene ID:4552
Ensembl ID:ENSG00000124275

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
NEURAL TUBEDEFECTS, FOLATE-SENSITIVEMTHFD1
MTHFR
MTHFR
MTR

Cytogenetic Location (from UniGene)

Cytogenetic Location:5p15.31Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 7869274 - 7901235

 Exon Info From UCSC:
NM_002454
NM_024010

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5205285Full LengthBC0548165-methyltetrahydrofolate-homocysteine methyltransferase reductase
40007734Full LengthBC1092165-methyltetrahydrofolate-homocysteine methyltransferase reductase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_076915  NP_002445  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002454 NP_002445     NAD_binding_1
Flavodoxin_1
FAD_binding_1
NM_024010 NP_076915 Q9UBK8 EC 1.16.1.8 NAD_binding_1
Flavodoxin_1
FAD_binding_1

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF025794 AAC39667 Q9UBK8 EC 1.16.1.8
AF121214 AAF16876 Q9UBK8 EC 1.16.1.8
BC054816 AAH54816 Q9UBK8 EC 1.16.1.8
BC109216 AAI09217 Q9UBK8 EC 1.16.1.8

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MTRR NP_076915 R.norvegicus Mtrr 290947   NP_001034092 81
M.musculus Mtrr 210009 Gene Info NP_766068 79
C.elegans tag-165 174471   NP_495978 35

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)