Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. TOP2B, topoisomerase (DNA) II beta 180kDa
Sequence ID:NM_001068
Entrez Gene ID:7155
Ensembl ID:ENSG00000077097

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:3p24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 25639482 - 25683826

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100063468Full LengthBC157118topoisomerase (DNA) II beta 180kDa
4999541IncompleteBC021863topoisomerase (DNA) II beta 180kDa
100061836BC156330topoisomerase (DNA) II beta 180kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001059  

Protein Infomation

NM_001068 NP_001059   DNA_gyraseB

Related Sequences

M27504 AAA61210 Q02880 EC
U54831 AAB01982 Q02880 EC
BC021863 AAH21863 Q8WTY5  
BC156330 AAI56331    
BC157118 AAI57119    
AB208879 BAD92116 Q59H80  
AK296510 BAG59142 B4DKD0  
AK297171 BAG59664 B4DLV2  
AK316492 BAH14863 B7ZB27  
X53662 CAA37706 Q02880 EC
X68060 CAA48197 Q02880 EC
Z15111 CAA78815 Q02880 EC
Z15115 CAA78821 Q02880 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens TOP2B NP_001059 M.musculus Top2b 21974 Gene Info NP_033435 96

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta