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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. TOP1, topoisomerase (DNA) I
Sequence ID:NM_003286
RefSeqGene ID:NG_012262
Entrez Gene ID:7150
Ensembl ID:ENSG00000198900

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pineal gland, placenta, pooled tissue, prostate, salivary gland, skin, spleen, stem cell, stomach, synovium, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:20q12-q13.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 39657462 - 39709822

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9020284Full LengthBC136297topoisomerase (DNA) I
3448011IncompleteBC000943topoisomerase (DNA) I
3840528IncompleteBC004475topoisomerase (DNA) I
5578397IncompleteBC039009topoisomerase (DNA) I
6378027IncompleteBC067349topoisomerase (DNA) I

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003277  

Protein Infomation

NM_003286 NP_003277 P11387 EC Topoisom_I

Related Sequences

J03250 AAA61207 P11387 EC
M27913 AAA61208 P11387 EC
U07804 AAB60379 P11387 EC
U07806 AAB60380 P11387 EC
BC000943 AAH00943 Q9BVT2  
BC004475 AAH04475 Q6PK95  
BC067349 AAH67349 Q6NWZ5  
BC136297 AAI36298 B9EG90  
AK292943 BAF85632 P11387 EC
X16479 CAA34500 P11387 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens TOP1 NP_003277 M.musculus Top1 21969 Gene Info NP_033434 97
R.norvegicus Top1 64550   NP_072137 97
D.melanogaster Top1 32458   NP_001014742 63
A.gambiae AgaP_AGAP004078 1270877   XP_309629 62
C.elegans top-1 266847   NP_493337 59
S.cerevisiae TOP1 854156   NP_014637 46
S.pombe top1 2540032   NP_596209 46
N.crassa NCU09118 3874180   XP_958033 44
A.thaliana TOP1ALPHA 835623   NP_200341 43
A.thaliana TOP1BETA 835624   NP_200342 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)