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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PRNP, prion protein
Sequence ID:NM_000311
NM_001080121
NM_001080122
NM_001080123
NM_001271561
NM_183079
RefSeqGene ID:NG_009087
Entrez Gene ID:5621
Ensembl ID:ENSG00000171867

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, stem cell, stomach, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
CREUTZFELDT-JAKOB DISEASEHLA-DQB1
HLA-DQB1
GERSTMANN-STRAUSSLER DISEASE 
HUNTINGTON DISEASE-LIKE 1 
INSOMNIA, FATAL FAMILIAL 
KURU 
PRION DISEASE WITH PROTRACTED COURSE 

Cytogenetic Location (from UniGene)

Cytogenetic Location:20p13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 4679856 - 4681289

 Exon Info From UCSC:
NM_000311
NM_001080121
NM_001080122
NM_001080123
NM_183079

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3863784Full LengthBC012844prion protein
4813982Full LengthBC022532prion protein
4078124IncompleteBC016809prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000302  NP_898902  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000311 NP_000302 Q53YK7
P04156
Prion
Prion_octapep
NM_001080121 NP_001073590    
NM_001080122 NP_001073591    
NM_001080123 NP_001073592    
NM_001271561 NP_001258490 F7VJQ1  
NM_183079 NP_898902 Q53YK7
P04156
Prion
Prion_octapep

Related Sequences

 
mRNAGenPeptSwissProt
M13667 AAA19664 P04156
M13899 AAA60182 Q53YK7
P04156
AY008282 AAG21693 Q53YK7
P04156
BC012844 AAH12844 Q6FGN5
P04156
BC022532 AAH22532 P04156
AY569456 AAS80162 Q53YK7
P04156
BT019496 AAV38303 Q5U0K3
DQ891318 ABM82244  
DQ894502 ABM85428  
D00015 BAA00011 P04156
AB300823 BAG32276 Q53YK7
AB300825 BAG32278 B2NI04
AK312276 BAG35206 B2R5Q9
AK090575 BAG52189 B3KQX7
AK293312 BAG56832 B4DDS1
AK295415 BAG58365 B4DI53
AK295943 BAG58727 B4DJ65
CR542039 CAG46836 Q6FGR8
CR542072 CAG46869 Q6FGN5

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PRNP NP_000302 M.musculus Prnp 19122 Gene Info NP_035300 90
R.norvegicus Prnp 24686   NP_036763 90

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta