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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. IRS1, insulin receptor substrate 1
Sequence ID:NM_005544
RefSeqGene ID:NG_015830
Entrez Gene ID:3667
Ensembl ID:ENSG00000169047

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
DIABETES MELLITUS, NON-INSULIN-DEPENDENTABCC8
AKT2
CDKAL1
ENPP1
GCGR
GCK
GPD2
HMGA1
HMGA1
HNF1A
HNF1B
HNF4A
IGF2BP2
IL6
IRS2
KCNJ11
LIPC
MAPK8IP1
MTNR1B
NEUROD1
NEUROD1
NEUROD1
PAX4
PDX1
PPARG
PTPN1
RETN
SLC2A4
SLC30A8
TCF7L2
VEGFA
WFS1
WFS1

Cytogenetic Location (from UniGene)

Cytogenetic Location:2q36Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 227599763 - 227663506

NM_005544 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
94941227596033227600965
49428743227659704227663505

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6144252Full LengthBC053895insulin receptor substrate 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005535  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005544 NP_005535 P35568 PH
IRS

Related Sequences

 
mRNAGenPeptSwissProt
S62539 AAB27175 P35568
BC053895 AAH53895 P35568
EU831698 ACE86532  
EU831611 ACE87211  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens IRS1 NP_005535 R.norvegicus Irs1 25467   NP_037101 91
M.musculus Irs1 16367 Gene Info NP_034700 90

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta