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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. MTHFD2, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Sequence ID:NM_006636
NR_027405
NM_001040409
RefSeqGene ID:NG_029162
Entrez Gene ID:10797
Ensembl ID:ENSG00000065911

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p13.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 74425741 - 74442422

Transcript StartTranscript EndChromosomal Start Chromosomal End
11807442568974425868
1813657443283174433015
3664887443483074434952
4896417443569574435847
6427497443706874437175
7508427443832574438417
8439687443886774438992
96921857444120574442421

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3462450Full LengthBC001548methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
3846710Full LengthBC017054methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
4285669Full LengthBC015062methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_006627  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_006636 NP_006627 P13995 EC 3.5.4.9
EC 1.5.1.15
THF_DHG_CYH
THF_DHG_CYH_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC001548 AAH01548 P13995 EC 3.5.4.9
EC 1.5.1.15
BC015062 AAH15062 Q7Z650  
BC017054 AAH17054 P13995 EC 3.5.4.9
EC 1.5.1.15
DQ894679 ABM85605    
AK222826 BAD96546 P13995 EC 3.5.4.9
EC 1.5.1.15
AK223041 BAD96761 P13995 EC 3.5.4.9
EC 1.5.1.15
AK313138 BAG35957 B2R7W0  
AK300035 BAG61846 Q7Z650  
AK302245 BAG63597 B4DY35  
X16396 CAA34431 P13995 EC 3.5.4.9
EC 1.5.1.15

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MTHFD2 NP_006627 M.musculus Mthfd2 17768 Gene Info NP_032664 92
R.norvegicus Mthfd2 680308   NP_001102868 91
A.gambiae AgaP_AGAP004677 1275382   XP_001687783 62
D.melanogaster Nmdmc 47895   NP_476929 57

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)