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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. SIRT2, sirtuin 2
Sequence ID:NM_001193286
Entrez Gene ID:22933
Ensembl ID:ENSG00000068903

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:19q13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 39369208 - 39390227

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2820929Full LengthBC003012sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
3536728Full LengthBC003547sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_085096  NP_036369  

Protein Infomation

NM_001193286 NP_001180215    
NM_012237 NP_036369 Q8IXJ6 SIR2
NM_030593 NP_085096   SIR2

Related Sequences

AF131800 AAD20046 Q8IXJ6
AF083107 AAD40850 Q8IXJ6
AF095714 AAD45971 Q8IXJ6
AF160214 AAF67015 Q8IXJ6
BC003012 AAH03012 Q8IXJ6
BC003547 AAH03547 Q8IXJ6
AY030277 AAK51133 Q8IXJ6
EU447008 ABZ92537  
AB009274 BAF76655 A7VJH3
AK290716 BAF83405 Q8IXJ6
AK314492 BAG37092 Q8IXJ6
AJ505014 CAD43717 Q8IXJ6

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens SIRT2 NP_036369 M.musculus Sirt2 64383 Gene Info NP_071877 88
R.norvegicus Sirt2 361532   NP_001008369 87
N.crassa NCU00523 3879874   XP_963725 52
S.pombe hst2 2538868   NP_588147 52
A.gambiae AgaP_AGAP002943 1273019   XP_311957 51
D.melanogaster Sirt2 42414   NP_650880 51
S.cerevisiae HST2 856092   NP_015310 47

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)