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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. INSR, insulin receptor
Sequence ID:NM_000208
NM_001079817
RefSeqGene ID:NG_008852
Entrez Gene ID:3643
Ensembl ID:ENSG00000171105

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS 
HYPERINSULINEMIC HYPOGLYCEMIA, FAMILIAL, 5 
LEPRECHAUNISM 
RABSON-MENDENHALL SYNDROME 

Cytogenetic Location (from UniGene)

Cytogenetic Location:19p13.3-p13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 7116149 - 7166414

 Exon Info From UCSC:
NM_000208
NM_001079817

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40125723Full LengthBC117172insulin receptor
4823710IncompleteBC047591insulin receptor

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000199  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000208 NP_000199 P06213 EC 2.7.10.1 fn3
Pkinase
Furin-like
Recep_L_domain
Pkinase_Tyr
NM_001079817 NP_001073285      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M10051 AAA59174 P06213 EC 2.7.10.1
M24555 AAA59178 P06213 EC 2.7.10.1
BC047591 AAH47591 Q86WY9  
BC117172 AAI17173 P06213 EC 2.7.10.1
AB208861 BAD92098 P06213 EC 2.7.10.1
X02160 CAA26096 P06213 EC 2.7.10.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens INSR NP_000199 M.musculus Insr 16337 Gene Info NP_034698 96
R.norvegicus Insr 24954   NP_058767 95

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta