Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MAP2K2, mitogen-activated protein kinase kinase 2
Sequence ID:NM_030662
RefSeqGene ID:NG_007996
Entrez Gene ID:5605
Ensembl ID:ENSG00000126934

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
CARDIOFACIOCUTANEOUS SYNDROMEBRAF
KRAS
MAP2K1

Cytogenetic Location (from UniGene)

Cytogenetic Location:19p13.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 4090319 - 4124126

 Exon Info From UCSC:
NM_030662

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2961198Full LengthBC000471mitogen-activated protein kinase kinase 2
4025987Full LengthBC018645mitogen-activated protein kinase kinase 2

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_109587  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_030662 NP_109587 P36507 EC 2.7.12.2 Pkinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC000471 AAH00471 P36507 EC 2.7.12.2
BC018645 AAH18645 P36507 EC 2.7.12.2
DQ893601 ABM84527    
DQ895060 ABM85986    
AK129586 BAC85187 Q6ZPC5  
AK093125 BAG52659 B3KS97  
BX538081 CAD98005 Q7Z370  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MAP2K2 NP_109587 M.musculus Map2k2 26396 Gene Info NP_075627 94
R.norvegicus Map2k2 58960   NP_579817 94
N.crassa NCU04612 3875002   XP_958855 49
S.pombe byr1 2542137   NP_593026 48
A.thaliana MKK6 835759   NP_200469 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta