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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. CBFB, Core-binding factor, beta subunit
Sequence ID:NM_001755
NM_022845
RefSeqGene ID:NG_009281
Entrez Gene ID:865
Ensembl ID:ENSG00000067955

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEUKEMIA, ACUTE MYELOGENOUSARHGEF12
CEBPA
CHIC2
ETV6
FLT3
GATA2
GMPS
JAK2
KIT
LPP
MLF1
MLLT10
NPM1
NSD1
NUP214
PICALM
RUNX1
RUNX1
SH3GL1
TERT
WHSC1L1

Cytogenetic Location (from UniGene)

Cytogenetic Location:16q22.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:16: 67063310 - 67132842

 Exon Info From UCSC:
NM_001755
NM_022845

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3867061Full LengthBC018509core-binding factor, beta subunit

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001746  NP_074036  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001755 NP_001746 Q13951 CBF_beta
NM_022845 NP_074036   CBF_beta

Related Sequences

 
mRNAGenPeptSwissProt
L20298 AAA02868 Q13951
AF294326 AAG01553 Q13951
BC018509 AAH18509 Q13951
BT006862 AAP35508 Q13951
DQ893719 ABM84645  
DQ890558 ABM92175  
AK290462 BAF83151 Q13951
AK291834 BAF84523 A8K719

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CBFB NP_074036 M.musculus Cbfb 12400 Gene Info NP_071704 99
R.norvegicus Cbfb 361391   NP_001013209 97
D.melanogaster Bgb 38198   NP_477065 54
A.gambiae AgaP_AGAP000317 1271945   XP_310806 48

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)