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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. MTHFS, 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Sequence ID:NM_006441
RefSeqGene ID:NG_029243
Entrez Gene ID:10588
Ensembl ID:ENSG00000136371

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:15q25.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:15: 80137564 - 80189327

Transcript StartTranscript EndChromosomal Start Chromosomal End

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3900731Full LengthBC0199215,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
3858004IncompleteBC0124175,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_006432  

Protein Infomation

NM_001199758 NP_001186687      
NM_001199760 NP_001186689      
NM_006441 NP_006432 P49914 EC 5-FTHF_cyc-lig

Related Sequences

L38928 AAC41945 P49914 EC
BC012417 AAH12417 Q96EE9  
BC019921 AAH19921 P49914 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens MTHFS NP_006432 M.musculus Mthfs 107885 Gene Info NP_081105 85
M.musculus Gm2382 100039707 Gene Info NP_001122073 85
R.norvegicus Mthfs 300886   NP_001009349 83
A.gambiae AgaP_AGAP006824 1270240   XP_308920 41
C.elegans Y106G6E.4 190922   NP_492692 39
D.melanogaster CG34424 37699   NP_001097432 38
N.crassa NCU06353 3878526   XP_962387 37
A.thaliana 5-FCL 831144   NP_568284 33
S.cerevisiae FAU1 856932   NP_011110 32

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)