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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. IARS, isoleucyl-tRNA synthetase
Sequence ID:NM_002161
Entrez Gene ID:3376
Ensembl ID:ENSG00000196305

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:9q21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:9: 94973010 - 95055947

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6043344Full LengthBC065552isoleucyl-tRNA synthetase
3343584IncompleteBC008318isoleucyl-tRNA synthetase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002152  NP_038203  

Protein Infomation

NM_002161 NP_002152     tRNA-synt_1
NM_013417 NP_038203 P41252 EC tRNA-synt_1

Related Sequences

U04953 AAA80153 P41252 EC
BC008318 AAH08318 Q7L4K8  
BC065552 AAH65552 Q6P0M4  
EU832046 ACE86708    
EU831952 ACE87393    
D28473 BAA05835 P41252 EC
AB209234 BAD92471 Q59G75  
AK293014 BAF85703 P41252 EC
AK301272 BAG62834 B4DVX2  
BX537417 CAD97659 Q7Z3U5  
BX537429 CAD97671 P41252 EC
BX538109 CAD98022 Q7Z355  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens IARS NP_002152 M.musculus Iars 105148 Gene Info NP_742012 91
R.norvegicus Iars 306804   NP_001094042 91
A.gambiae AgaP_AGAP002101 1281143   XP_320939 60
C.elegans irs-1 177926   NP_501914 59
D.melanogaster Aats-ile 45785   NP_524840 58
A.thaliana AT4G10320 826624   NP_192770 56
S.pombe irs1 2541245   NP_595569 55
S.cerevisiae ILS1 852202   NP_009477 54
N.crassa NCU03575 3872164   XP_956014 53
P.falciparum PF13_0179 814149   XP_001350060 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)