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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. GRB2, Growth factor receptor-bound protein 2
Sequence ID:NM_002086
RefSeqGene ID:NG_029556
Entrez Gene ID:2885
Ensembl ID:ENSG00000177885

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:17q24-q25Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 73314156 - 73315037

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3345524Full LengthBC000631growth factor receptor-bound protein 2
4649400IncompleteBC019082growth factor receptor-bound protein 2
5417009IncompleteBC043007growth factor receptor-bound protein 2

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002077  

Protein Infomation

NM_002086 NP_002077 P62993 SH2
NM_203506 NP_987102    

Related Sequences

M96995 AAA58448 P62993
L29511 AAC37549 P62993
AF302079 AAG27442  
AF246238 AAG44485  
BC000631 AAH00631 P62993
AF498925 AAM21073 P62993
AF171699 AAQ13606  
DQ891830 ABM82756  
DQ894923 ABM85849  
AK024539 BAB14923  
AK315565 BAG37940 B0LPF3
AK091010 BAG52262 B3KR50
X62852 CAA44664 P62993
CR450363 CAG29359 Q6ICN0
CR541942 CAG46740 P62993

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens GRB2 NP_002077 M.musculus Grb2 14784 Gene Info NP_032189 100
R.norvegicus Grb2 81504   NP_110473 100
D.melanogaster drk 36497   NP_725303 67
A.gambiae AgaP_AGAP011768 1280872   XP_320742 66
C.elegans sem-5 181055   NP_509342 59

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta