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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. IRS2, insulin receptor substrate 2
Sequence ID:NM_003749
RefSeqGene ID:NG_008154
Entrez Gene ID:8660
Ensembl ID:ENSG00000185950

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
DIABETES MELLITUS, NON-INSULIN-DEPENDENTABCC8
AKT2
CDKAL1
ENPP1
GCGR
GCK
GPD2
HMGA1
HMGA1
HNF1A
HNF1B
HNF4A
IGF2BP2
IL6
IRS1
KCNJ11
LIPC
MAPK8IP1
MTNR1B
NEUROD1
NEUROD1
NEUROD1
PAX4
PDX1
PPARG
PTPN1
RETN
SLC2A4
SLC30A8
TCF7L2
VEGFA
WFS1
WFS1

Cytogenetic Location (from UniGene)

Cytogenetic Location:13q34Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:13: 110406183 - 110438915

NM_003749 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
192488110406185110408654
24897014110434388110438913

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3860131IncompleteBC012414insulin receptor substrate 2
5303945IncompleteBC042858insulin receptor substrate 2

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003740  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_003749 NP_003740 Q9Y4H2 PH
IRS

Related Sequences

 
mRNAGenPeptSwissProt
AF073310 AAD21531 Q9Y4H2
AF161416 AAF28976 Q9P084

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens IRS2 NP_003740 M.musculus Irs2 384783 Gene Info NP_001074681 87
R.norvegicus Irs2 29376   NP_001162104 87

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)