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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. MANF, mesencephalic astrocyte-derived neurotrophic factor
Sequence ID:NM_006010
RefSeqGene ID:NG_012652
Entrez Gene ID:7873
Ensembl ID:ENSG00000145050

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebrum, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, soft tissue, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes

Cytogenetic Location (from UniGene)

Cytogenetic Location:3p21.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 51422754 - 51426768

NM_006010 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
8322640Full LengthBC113588arginine-rich, mutated in early stage tumors
8322642Full LengthBC113590arginine-rich, mutated in early stage tumors
3343642IncompleteBC007282arginine-rich, mutated in early stage tumors

Protein Infomation

NM_006010 NP_006001 P55145  

Related Sequences

M83751 AAB08753 P55145
BC007282 AAH07282 P55145
BC113588 AAI13589 P55145
BC113590 AAI13591 P55145
BT007110 AAP35774 P55145
EU832733 ACE87065  
EU832655 ACE87746  
AK292243 BAF84932 A8K878

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens MANF NP_006001 M.musculus Manf 74840 Gene Info NP_083379 98
A.gambiae AgaP_AGAP003016 1272937   XP_311862 55
D.melanogaster Manf 41983   NP_477445 55
C.elegans Y54G2A.23 177074   NP_500273 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)