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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. TOP3B, Topoisomerase (DNA) III beta
Sequence ID:NM_003935
Entrez Gene ID:8940
Ensembl ID:ENSG00000100038

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, skin, spleen, stem cell, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:22q11.22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:22: 22311403 - 22337141

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3346377Full LengthBC002432topoisomerase (DNA) III beta

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003926  

Protein Infomation

NM_003935 NP_003926 O95985 EC Topoisom_bac

Related Sequences

AF017146 AAD01614 O95985 EC
AF053082 AAD15791 O95985 EC
AF125216 AAD29670 O95985 EC
BC002432 AAH02432 O95985 EC
AK290997 BAF83686 A8K4N2  
AK096695 BAG53351 B3KU89  
AK304709 BAG65474 B4E3G2  
CR456596 CAG30482 O95985 EC
CU013196 CAK54627    
CU013484 CAK54926    

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens TOP3B NP_003926 M.musculus Top3b 21976 Gene Info NP_035754 96
R.norvegicus Top3b 287930   NP_001099331 95
D.melanogaster Top3beta 31565   NP_511059 59
A.thaliana AT2G32000 817760   NP_180760 55
C.elegans Y48C3A.14 174978   NP_496822 55

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)