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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. PAK1, p21 protein (Cdc42/Rac)-activated kinase 1
Sequence ID:NM_001128620
RefSeqGene ID:NG_029900
Entrez Gene ID:5058
Ensembl ID:ENSG00000149269

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q13-q14Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 77034134 - 77103576

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40034484Full LengthBC109299p21 protein (Cdc42/Rac)-activated kinase 1
5763796IncompleteBC050377p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
40034481IncompleteBC109298p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002567  

Protein Infomation

NM_001128620 NP_001122092      
NM_002576 NP_002567 Q13153 EC Pkinase

Related Sequences

U24152 AAA65441 Q13153 EC
AF071884 AAC24716 Q13153 EC
U51120 AAC50590 Q13153 EC
BC109299 AAI09300 Q13153 EC
EU832767 ACE87778    
GQ129310 ACT64444    
AK293098 BAF85787 A8KAN3  
AK055228 BAG51489 B3KNX7  
AK295344 BAH12038 B7Z302  
AK296006 BAH12236 B7Z3K0  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens PAK1 NP_002567 R.norvegicus Pak1 29431   NP_058894 99
M.musculus Pak1 18479 Gene Info NP_035165 99
A.gambiae AgaP_AGAP002986 1272970   XP_311901 73
D.melanogaster Pak 44039   NP_731074 68
C.elegans pak-1 180873   NP_001024377 63
S.cerevisiae STE20 856382   NP_011856 55
S.pombe shk1 2539997   NP_596626 53
N.crassa NCU03894 3873759   XP_957533 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta