Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. XRN1, 5'-3' exoribonuclease 1
Sequence ID:NM_001042604
Entrez Gene ID:54464
Ensembl ID:ENSG00000114127

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:3q23Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 142135998 - 142166904

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6015120IncompleteBC0781465'-3' exoribonuclease 1
100014585BC1415555'-3' exoribonuclease 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_061874  

Protein Infomation

NM_001042604 NP_001036069    
NM_019001 NP_061874 Q8IZH2 XRN_N

Related Sequences

BC039314 AAH39314 Q8IZH2
BC048104 AAH48104 Q8IZH2
BC141555 AAI41556  
AY137776 AAN11306 Q8IZH2
AK096177 BAC04718 Q8IZH2
AK123897 BAG53979 B3KW17
AK304312 BAG65165 B4E2K3
AL133623 CAB63749 Q8IZH2
BX640905 CAE45950 Q8IZH2
CR627396 CAH10490 Q8IZH2
CR749518 CAH18332 Q8IZH2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens XRN1 NP_061874 M.musculus Xrn1 24127 Gene Info NP_036046 89
R.norvegicus Xrn1 300944   XP_002730002 89
A.gambiae AgaP_AGAP004430 1274572   XP_313715 46
C.elegans xrn-1 175059   NP_496945 43
D.melanogaster pcm 32935   NP_001162796 43
S.pombe exo2 2542204   NP_593482 41
N.crassa NCU06678 3877063   XP_960925 41
S.cerevisiae KEM1 852702   NP_011342 38

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)