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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. HERC2, HECT and RLD domain containing E3 ubiquitin protein ligase 2
Sequence ID:NM_004667
RefSeqGene ID:NG_016355
Entrez Gene ID:8924
Ensembl ID:ENSG00000128731

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes

Cytogenetic Location (from UniGene)

Cytogenetic Location:15q13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:15: 28356187 - 28567250

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5262032IncompleteBC045544hect domain and RLD 2
9094352IncompleteBC172191hect domain and RLD 2
9094487IncompleteBC172911hect domain and RLD 2
40121629IncompleteBC148318hect domain and RLD 2

Protein Infomation

NM_004667 NP_004658 O95714  

Related Sequences

AF071172 AAD08657 O95714
BC148318 AAI48319 A8KAQ8
AL834183 CAD38880 Q8ND39

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens HERC2 NP_004658 M.musculus Herc2 15204 Gene Info NP_034548 96
R.norvegicus Herc2 308669   NP_001100990 96
A.gambiae AgaP_AGAP011823 1280824   XP_552411 49
D.melanogaster HERC2 33035   NP_608388 48

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)