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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. SHC1, SHC (Src homology 2 domain containing) transforming protein 1
Sequence ID:NM_001130040
RefSeqGene ID:NG_029028
Entrez Gene ID:6464
Ensembl ID:ENSG00000160691

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:1q21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 154936280 - 154943002

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4541216Full LengthBC014158SHC (Src homology 2 domain containing) transforming protein 1
4896385Full LengthBC033925SHC (Src homology 2 domain containing) transforming protein 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_892113  NP_003020  

Protein Infomation

NM_001130040 NP_001123512    
NM_001130041 NP_001123513    
NM_001202859 NP_001189788    
NM_003029 NP_003020   SH2
NM_183001 NP_892113 P29353 SH2

Related Sequences

U73377 AAB49972 P29353
BC014158 AAH14158 P29353
BC033925 AAH33925 P29353
HQ448284 ADQ32764  
AB208849 BAD92086 Q59HB0
AK292143 BAF84832 P29353
AK315842 BAF98733 P29353
AK296786 BAG59364 B4DL02
AB451255 BAG70069 P29353
AB451379 BAG70193 P29353
X68148 CAA48251 P29353

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens SHC1 NP_001123512 M.musculus Shc1 20416 Gene Info NP_001106802 95
R.norvegicus Shc1 85385   NP_001157532 95

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta