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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MAPK1, mitogen-activated protein kinase 1
Sequence ID:NM_002745
NM_138957
RefSeqGene ID:NG_023054
Entrez Gene ID:5594
Ensembl ID:ENSG00000100030

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, adrenal medulla, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:22q11.21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:22: 22114609 - 22116824

 Exon Info From UCSC:
NM_002745
NM_138957

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4685557Full LengthBC017832mitogen-activated protein kinase 1
5264558Full LengthBC099905mitogen-activated protein kinase 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002736  NP_620407  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002745 NP_002736 P28482 EC 2.7.11.24 Pkinase
NM_138957 NP_620407 P28482 EC 2.7.11.24 Pkinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC017832 AAH17832 P28482 EC 2.7.11.24
BC099905 AAH99905 Q499G7  
DQ399292 ABD60303 A8CZ64  
EU176323 ABW03774    
EU831522 ACE86441    
EU831429 ACE87116    
AK295188 BAG58192 B4DHN0  
Z11694 CAA77752 P28482 EC 2.7.11.24
Z11695 CAA77753 P28482 EC 2.7.11.24

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MAPK1 NP_002736 R.norvegicus Mapk1 116590   NP_446294 99
M.musculus Mapk1 26413 Gene Info NP_036079 99
A.gambiae AgaP_AGAP009207 1280167   XP_319983 88
D.melanogaster rl 3354888   NP_001104349 82
C.elegans mpk-1 175545   NP_001022583 81
S.cerevisiae KSS1 852931   NP_011554 54
A.thaliana MPK6 818982   NP_181907 53

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta