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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. PTPN1, Protein tyrosine phosphatase, non-receptor type 1
Sequence ID:NM_002827
RefSeqGene ID:NG_012119
Entrez Gene ID:5770
Ensembl ID:ENSG00000196396

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
DIABETES MELLITUS, NON-INSULIN-DEPENDENTABCC8
AKT2
CDKAL1
ENPP1
GCGR
GCK
GPD2
HMGA1
HMGA1
HNF1A
HNF1B
HNF4A
IGF2BP2
IL6
IRS1
IRS2
KCNJ11
LIPC
MAPK8IP1
MTNR1B
NEUROD1
NEUROD1
NEUROD1
PAX4
PDX1
PPARG
RETN
SLC2A4
SLC30A8
TCF7L2
VEGFA
WFS1
WFS1

Cytogenetic Location (from UniGene)

Cytogenetic Location:20q13.1-q13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 49126890 - 49199734

NM_002827 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
12374912689049127126
2383284917789949177989
3294294918150549181605
4305284918491649185014
5296664919105349191190
6678764919495649195165
87710384919570449195865
103912624919623949196462
126314584919780149197996
145933144919922849201083

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4338750Full LengthBC018164protein tyrosine phosphatase, non-receptor type 1
4844022Full LengthBC015660protein tyrosine phosphatase, non-receptor type 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002818  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002827 NP_002818 P18031 EC 3.1.3.48 Y_phosphatase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M33689 AAA60157 P18031 EC 3.1.3.48
M31724 AAA60223 P18031 EC 3.1.3.48
BC015660 AAH15660 P18031 EC 3.1.3.48
BC018164 AAH18164 P18031 EC 3.1.3.48
BT006752 AAP35398 P18031 EC 3.1.3.48
AK290638 BAF83327 A8K3M3  
AK316563 BAG38152 A8K3M3  
AK299830 BAG61697 B4DSN5  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PTPN1 NP_002818 R.norvegicus Ptpn1 24697   NP_036769 85
M.musculus Ptpn1 19246 Gene Info NP_035331 84
A.gambiae AgaP_AGAP005352 1276060   XP_315365 51
D.melanogaster Ptp61F 38160   NP_476687 51

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)