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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. HMGCS1, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Sequence ID:NM_001098272
Entrez Gene ID:3157
Ensembl ID:ENSG00000112972

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, placenta, pooled tissue, prostate, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:5p14-p13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 43289497 - 43313514

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4443624Full LengthBC0835143-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
2819708IncompleteBC0002973-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
3677631IncompleteBC0822343-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002121  

Protein Infomation

NM_001098272 NP_001091742 Q01581 EC  
NM_002130 NP_002121 Q5XJ04   HMG_CoA_synt_N

Related Sequences

L25798 AAA62411 Q01581 EC
BC000297 AAH00297 Q01581 EC
BC083514 AAH83514 Q5XJ04  
BT007302 AAP35966 Q01581 EC
AK095492 BAC04559 Q8N995  
AK315593 BAG37965 Q01581 EC
X66435 CAA47061 Q01581 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens HMGCS1 NP_002121 R.norvegicus Hmgcs1 29637   NP_058964 95
M.musculus Hmgcs1 208715 Gene Info NP_666054 95
M.musculus LOC100040592 100040592   XP_001475239 95
D.melanogaster Hmgs 44154   NP_725567 65
A.gambiae AgaP_AGAP005847 1276514   XP_315872 64
N.crassa NCU03922 3873746   XP_957561 53
S.cerevisiae ERG13 854913   NP_013580 51
A.thaliana MVA1 826788   NP_192919 50
S.pombe hcs1 2543141   NP_593859 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta