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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. HLCS, Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Sequence ID:NM_001242784
NM_001242785
NM_000411
RefSeqGene ID:NG_016193
Entrez Gene ID:3141
Ensembl ID:ENSG00000159267

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, stem cell, stomach, t-cell, testis, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
HOLOCARBOXYLASE SYNTHETASE DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:21q22.13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:21: 38309467 - 38352928


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
30343493Full LengthBC060787holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000402  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000411 NP_000402 P50747 EC 6.3.4.11
EC 6.3.4.15
EC 6.3.4.9
EC 6.3.4.10
BPL_C
BPL_LipA_LipB
NM_001242784 NP_001229713      
NM_001242785 NP_001229714      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC060787 AAH60787 P50747 EC 6.3.4.11
EC 6.3.4.15
EC 6.3.4.9
EC 6.3.4.10
D23672 BAA04902 P50747 EC 6.3.4.11
EC 6.3.4.15
EC 6.3.4.9
EC 6.3.4.10
D87328 BAA13332 P50747 EC 6.3.4.11
EC 6.3.4.15
EC 6.3.4.9
EC 6.3.4.10
AK314189 BAG36868 B2RAH1  
AJ001864 CAA05056 P50747 EC 6.3.4.11
EC 6.3.4.15
EC 6.3.4.9
EC 6.3.4.10

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HLCS NP_000402 M.musculus Hlcs 110948 Gene Info NP_631884 77
R.norvegicus Hlcs 288240   XP_221630 77
A.gambiae AgaP_AGAP001481 1281690   XP_321640 36
D.melanogaster Hcs 40659   NP_649542 35
A.thaliana HCS1 817112   NP_850067 33
A.thaliana HCS2 840632   NP_850957 32
C.elegans bpl-1 174039   NP_495257 30

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)