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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. COMT, catechol-O-methyltransferase
Sequence ID:NM_000754
NM_001135161
NM_001135162
NM_007310
RefSeqGene ID:NG_011526
Entrez Gene ID:1312
Ensembl ID:ENSG00000093010

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, soft tissue, stem cell, stomach, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
PANIC DISORDER 
SCHIZOAFFECTIVEDISORDERAKT1
APOL1
APOL2
APOL4
CHI3L1
CHI3L1
DAO
DAOA
DISC1
DISC2
DRD3
DTNBP1
HTR2A
LGR4
MTHFR
MTHFR
RTN4R
SYN2

Cytogenetic Location (from UniGene)

Cytogenetic Location:22q11.21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:22: 19938574 - 19940168

 Exon Info From UCSC:
NM_000754
NM_001135161
NM_001135162
NM_007310

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2964400Full LengthBC000419catechol-O-methyltransferase
2964400Full LengthBC005867catechol-O-methyltransferase
3503220Full LengthBC011935catechol-O-methyltransferase
6163659Full LengthBC100018catechol-O-methyltransferase

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000754 NP_000745 P21964 EC 2.1.1.6  
NM_001135161 NP_001128633      
NM_001135162 NP_001128634      
NM_007310 NP_009294      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M65212 AAA68927 P21964 EC 2.1.1.6
M65213 AAA68928 P21964 EC 2.1.1.6
M58525 AAA68929 P21964 EC 2.1.1.6
BC000419 AAH00419 Q9BWC7  
BC005867 AAH05867 Q9BWC7  
BC011935 AAH11935 P21964 EC 2.1.1.6
BC100018 AAI00019 P21964 EC 2.1.1.6
BT007125 AAP35789 Q7KZP0  
DQ893411 ABM84337    
DQ896732 ABM87731    
EF217321 ABN14344 A3F7Q5  
EF217322 ABN14345 A3F7Q6  
FJ410131 ACJ38231 B8XPJ7  
FJ410132 ACJ38232 B8XPJ8  
AK290440 BAF83129 P21964 EC 2.1.1.6
CR456422 CAG30308 P21964 EC 2.1.1.6
CR456997 CAG33278 P21964 EC 2.1.1.6
CU012983 CAK54414    
CU013271 CAK54713    

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens COMT NP_000745 M.musculus Comt 12846 Gene Info NP_031770 80
R.norvegicus Comt 24267   NP_036663 79
N.crassa NCU07919 3878607   XP_962435 41
S.pombe SPBC119.03 2540074   NP_595284 41
S.pombe SPBPB21E7.04c 3361178   NP_001018770 39

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)