Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. SIRT1, sirtuin 1
Sequence ID:NM_001142498
NM_012238
Entrez Gene ID:23411
Ensembl ID:ENSG00000096717

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:10q21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 69644426 - 69678139

 Exon Info From UCSC:
NM_001142498
NM_012238

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4518906Full LengthBC012499sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_036370  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001142498 NP_001135970    
NM_012238 NP_036370 Q96EB6 SIR2

Related Sequences

 
mRNAGenPeptSwissProt
AF083106 AAD40849 Q96EB6
AF235040 AAG38486 Q96EB6
BC012499 AAH12499 Q96EB6
JQ768366 AFI98394 I1Y8W7
AK289743 BAF82432 A8K128
AK027686 BAG51365 B3KNK3
AK074805 BAG52006 B0QZ35

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens SIRT1 NP_036370 M.musculus Sirt1 93759 Gene Info NP_062786 88
C.elegans sir-2.1 177924   NP_501912 42

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta