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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. SIRT1, Sirtuin 1
Sequence ID:NM_012238
Entrez Gene ID:23411
Ensembl ID:ENSG00000096717

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 69644426 - 69678139

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4518906Full LengthBC012499sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_036370  

Protein Infomation

NM_001142498 NP_001135970    
NM_012238 NP_036370 Q96EB6 SIR2

Related Sequences

AF083106 AAD40849 Q96EB6
AF235040 AAG38486 Q96EB6
BC012499 AAH12499 Q96EB6
JQ768366 AFI98394 I1Y8W7
AK289743 BAF82432 A8K128
AK027686 BAG51365 B3KNK3
AK074805 BAG52006 B0QZ35

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens SIRT1 NP_036370 M.musculus Sirt1 93759 Gene Info NP_062786 88
C.elegans sir-2.1 177924   NP_501912 42

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta