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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. DYRK1A, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Sequence ID:NM_130436
RefSeqGene ID:NG_009366
Entrez Gene ID:1859
Ensembl ID:ENSG00000157540

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes

Cytogenetic Location (from UniGene)

Cytogenetic Location:21q22.13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:21: 38739235 - 38858783

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100069199Full LengthBC172505dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
100061742BC156309dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001387  

Protein Infomation

NM_001396 NP_001387 Q13627 EC Pkinase
NM_101395 NP_567824      
NM_130436 NP_569120      
NM_130438 NP_569122      

Related Sequences

U52373 AAB18639 Q13627 EC
U58496 AAC50939 Q13627 EC
AF108830 AAD31169 Q13627 EC
BC156309 AAI56310    
BC172505 AAI72505    
D85759 BAA12866 Q13627 EC
D86550 BAA13110 Q13627 EC
AB015282 BAA33975 O94789  
AB015283 BAA33976 Q76N25  
AB015284 BAA33977 Q76N25  
AK301752 BAG63214 B4DX02  
AJ001870 CAA05059 Q13627 EC
AJ001871 CAA05060 O60770  
Z25423 CAA80910 Q15446  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens DYRK1A NP_001387 R.norvegicus Dyrk1a 25255   NP_036923 100
M.musculus Dyrk1a 13548 Gene Info NP_001106860 99

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta