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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. FECH, ferrochelatase
Sequence ID:NM_000140
RefSeqGene ID:NG_008175
Entrez Gene ID:2235
Ensembl ID:ENSG00000066926

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, placenta, pooled tissue, prostate, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes

Cytogenetic Location (from UniGene)

Cytogenetic Location:18q21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:18: 55216741 - 55253886

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6042757Full LengthBC039841ferrochelatase (protoporphyria)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000131  NP_001012533  

Protein Infomation

NM_000140 NP_000131 P22830 EC Ferrochelatase
NM_001012515 NP_001012533     Ferrochelatase

Related Sequences

BC039841 AAH39841 P22830 EC
BT019958 AAV38761 P22830 EC
BT019959 AAV38762 Q5TZY0  
D00726 BAA00628 P22830 EC
AK092416 BAC03882 P22830 EC
AK223190 BAD96910 Q53FU1  
AK292937 BAF85626 P22830 EC
AK299643 BAG61566 B4DSA4  
BX571744 CAE11869 Q7KZA3  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens FECH NP_000131 M.musculus Fech 14151 Gene Info NP_032024 89
R.norvegicus Fech 361338   NP_001101904 89
A.gambiae AgaP_AGAP003719 1271452   XP_310249 58
N.crassa NCU08291 3878670   XP_962504 57
D.melanogaster ferrochelatase 43757   NP_524613 56
S.cerevisiae HEM15 854347   NP_014819 52
S.pombe hem15 2539199   NP_587720 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta