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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. BRCA2, breast cancer 2, early onset
Sequence ID:NM_000059
RefSeqGene ID:NG_012772
Entrez Gene ID:675
Ensembl ID:ENSG00000139618

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3
BREAST-OVARIAN CANCER, FAMILIAL, 2 
FANCONI ANEMIA, COMPLEMENTATION GROUP AFANCA
FANCB
FANCC
FANCD2
FANCE
FANCF
FANCG
FANCONI ANEMIA,COMPLEMENTATION GROUP D1 
GLIOBLASTOMADMBT1
ERBB2
LGI1
MSH2
PPARG
PTEN
WDR11
GLIOBLASTOMA 3 
MEDULLOBLASTOMAABR
APC
APC
CTNNB1
DMBT1
PTCH1
PTCH2
SUFU
PANCREATIC CANCERKRAS
MANF
PALLD
TP53
TP53
PANCREATIC CANCER 
PROSTATE CANCERAR
CD82
CDH1
CHEK2
CHEK2
ELAC2
HIP1
HIP1
HNF1B
KLF6
KLF6
MAD1L1
MSR1
MXI1
MXI1
PTEN
TUSC3
TUSC3
ZFHX3
WILMS TUMORGPC3
WT1

Cytogenetic Location (from UniGene)

Cytogenetic Location:13q12.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:13: 32889641 - 32907422

 Exon Info From UCSC:
NM_000059

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4838723IncompleteBC026160breast cancer 2, early onset
4838724IncompleteBC047568breast cancer 2, early onset

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000050  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000059 NP_000050   BRCA2

Related Sequences

 
mRNAGenPeptSwissProt
U43746 AAB07223 P51587
DQ897648 ABI74674 A1YBP1
GU014835 ACX32322  
JX480468 AFU88810  
JX480469 AFU88811  
JX480470 AFU88812  
JX480471 AFU88813  
JX480473 AFU88815  
JX480474 AFU88816  
JX480476 AFU88818  
JX480477 AFU88819  
JX480478 AFU88820  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens BRCA2 NP_000050 M.musculus Brca2 12190 Gene Info NP_033895 60
R.norvegicus Brca2 360254   NP_113730 59

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta