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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. GCLM, glutamate-cysteine ligase, modifier subunit
Sequence ID:NM_002061
RefSeqGene ID:NG_012072
Entrez Gene ID:2730
Ensembl ID:ENSG00000023909

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
MYOCARDIAL INFARCTIONESR1
F13A1
F7
GCLC
ITGB3
LGALS2
LRP8
LTA
MIAT
OLR1
PSMA6
THBD
TNFSF4

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p22.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 94354508 - 94375154

NM_002061 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
121269435258994354714
212722419436016994360283
224224449436217394362375
244525049436339494363453
250525899436714094367224
259026559437007894370143
265630749437459394375011

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5311598Full LengthBC041809glutamate-cysteine ligase, modifier subunit

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_002061 NP_002052 P48507  

Related Sequences

 
mRNAGenPeptSwissProt
L35546 AAA65028 P48507
BC041809 AAH41809 P48507
AK290449 BAF83138 P48507
CR541833 CAG46632 P48507

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens GCLM NP_002052 M.musculus Gclm 14630 Gene Info NP_032155 96
R.norvegicus Gclm 29739   NP_059001 96
A.gambiae AgaP_AGAP012038 1280630   XP_320488 37
D.melanogaster Gclm 248194   NP_732780 36
C.elegans E01A2.1 171998   NP_001122439 35

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)