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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. KARS, lysyl-tRNA synthetase
Sequence ID:NM_001130089
RefSeqGene ID:NG_028025
Entrez Gene ID:3735
Ensembl ID:ENSG00000065427

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes

Cytogenetic Location (from UniGene)

Cytogenetic Location:16q23.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:16: 75661792 - 75681563

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2963032Full LengthBC004132lysyl-tRNA synthetase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005539  

Protein Infomation

NM_001130089 NP_001123561      
NM_005548 NP_005539 Q15046 EC tRNA-synt_2

Related Sequences

AF285758 AAG30114 Q15046 EC
BC004132 AAH04132 Q15046 EC
DQ892301 ABM83227    
DQ895500 ABM86426    
D31890 BAA06688 Q15046 EC
D32053 BAA22084 Q15046 EC
AK126584 BAC86604 Q6ZTI3  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens KARS NP_001123561 R.norvegicus Kars 292028   NP_001006968 92
M.musculus Kars 85305 Gene Info NP_001124340 92
A.gambiae AgaP_AGAP000325 1271935   XP_310792 70
D.melanogaster Aats-lys 31904   NP_727353 68
S.pombe krs1 2539746   NP_595892 61
C.elegans krs-1 174159   NP_495453 60
S.cerevisiae KRS1 851607   NP_010322 59
A.thaliana ATKRS-1 820343   NP_187777 58
N.crassa NCU04020 3873822   XP_957635 54
P.falciparum PF13_0262 814227   XP_001350214 53

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)