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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. ROCK1, Rho-associated, coiled-coil containing protein kinase 1
Sequence ID:NM_005406
Entrez Gene ID:6093
Ensembl ID:ENSG00000067900

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:18q11.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:18: 18547821 - 18619510

 Exon Info From UCSC:
NM_005406

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
7961989Full LengthBC113114Rho-associated, coiled-coil containing protein kinase 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005397  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_005406 NP_005397 Q13464 EC 2.7.11.1 Pkinase
C1_1
PH
Pkinase_C
HR1

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U43195 AAB02814 Q13464 EC 2.7.11.1
BC113114 AAI13115 Q13464 EC 2.7.11.1
AB208965 BAD92202 Q13464 EC 2.7.11.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens ROCK1 NP_005397 M.musculus Rock1 19877 Gene Info NP_033097 97
R.norvegicus Rock1 81762   NP_112360 96

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta