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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. PTGIS, prostaglandin I2 (prostacyclin) synthase
Sequence ID:NM_000961
RefSeqGene ID:NG_007940
Entrez Gene ID:5740
Ensembl ID:ENSG00000124212

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
HYPERTENSIONADD1
AGT
AGTR1
AGTR1
ATP1B1
ATP1B1
CYP3A5
ECE1
GNB3
NOS2
NOS3
RGS5
RGS5
SELE

Cytogenetic Location (from UniGene)

Cytogenetic Location:20q13.13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 48124456 - 48184653

NM_000961 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
341914812041248124600
419243434812756448127715
434445254812961648129797
452646944813076348130931
469548764814059448140775
487750284815610648156257
502951724816084148160984
517353514816437748164555
535254754816660248166725
547656034818457948184706

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
8069315Full LengthBC101809prostaglandin I2 (prostacyclin) synthase
8069317Full LengthBC101811prostaglandin I2 (prostacyclin) synthase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000952  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000961 NP_000952 Q16647 EC 5.3.99.4 p450

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF297048 AAG31781 Q16647 EC 5.3.99.4
AF297049 AAG31782 Q16647 EC 5.3.99.4
AF297050 AAG31783 Q16647 EC 5.3.99.4
AF297051 AAG31784 Q16647 EC 5.3.99.4
AF297052 AAG31785 Q16647 EC 5.3.99.4
BC101809 AAI01810 Q16647 EC 5.3.99.4
BC101811 AAI01812 Q16647 EC 5.3.99.4
D38145 BAA07343 Q16647 EC 5.3.99.4

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PTGIS NP_000952 M.musculus Ptgis 19223 Gene Info NP_032994 86
R.norvegicus Ptgis 25527   NP_113745 84

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta