Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. EIF2B5, eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Sequence ID:NM_003907
RefSeqGene ID:NG_015826
Entrez Gene ID:8893
Ensembl ID:ENSG00000145191

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTEREIF2B1
EIF2B2
EIF2B3
EIF2B4

Cytogenetic Location (from UniGene)

Cytogenetic Location:3q27.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 183853173 - 183863098

 Exon Info From UCSC:
NM_003907

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3876105Full LengthBC013590eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003898  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_003907 NP_003898 Q13144 Hexapep
W2

Related Sequences

 
mRNAGenPeptSwissProt
U23028 AAC50646 Q13144
BC013590 AAH13590 Q13144
DQ891483 ABM82409  
DQ894670 ABM85596  
AK091646 BAC03712 Q13144
AB208821 BAD92058 Q59HD8

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens EIF2B5 NP_003898 R.norvegicus Eif2b5 192234   NP_620221 89
M.musculus Eif2b5 224045 Gene Info NP_758469 89
A.gambiae AgaP_AGAP000082 5666778   XP_001687758 35
A.thaliana AT2G34970 818061   NP_181042 35
A.thaliana AT4G18300 827556   NP_193564 35
A.thaliana AT3G02270 821200   NP_186876 34
S.pombe tif225 2542017   NP_594285 34
D.melanogaster eIF2B-epsilon 31156   NP_569961 33
S.cerevisiae GCD6 851797   NP_010497 31

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta